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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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Viagra is the brand name for the drug sildenafil. How does Viagra work? Sildenafil works by blocking the enzyme phosphodiesterase type 5 (PDE5), which is responsible for breaking down a molecule thatdeutsch. This allows blood vessels in the penis to get enough blood to work during an erection. Viagra is usually taken 1–2 hours before sex, making it easier for men to get and keep an erection.

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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

Take Control of Your Sex Life

Don’t let ED affect your confidence or relationships. Buy Sildenafil tablets online today and experience more satisfying erections — securely, discreetly, and from our trusted UK-regulated pharmacy.

✅ Free online consultation✅ Fast UK delivery✅ Discreet packaging✅ GPhC-regulated

now and get back to enjoying intimacy with confidence.

Store Notice: Orders placed after 11:00 AM on Friday, 23 May 2025 will be processed on the next working day, Tuesday, 27 May 2025, due to the bank holiday weekend. Thank you for your understanding.

Side Effects for Patients

Warning

Not All Men Who Take Medicationsll Must Keep This Product In Case You Use It In order to prevent an allergic reaction. This product may cause health risks if used in combination with medicines such as nitrates, alpha-blockers, and antibiotics. Many men do not get them, and want them stopped. To stop this product from causing health risks, read the enclosed leaflet before use. If you have any questions or concerns about your health, please speak to your doctor.Patient Information Leaflet

Do not use Sildenafil if you are allergic to sildenafil or any of the ingredients listed at the end of this leaflet. If you are not sure, talk to your doctor or pharmacist.

1. Introduction

Sildenafil citrate (Viagra) is an oral prescription medication that has revolutionized the treatment of erectile dysfunction (ED). This prescription medication helps men regain their sexual function by increasing blood flow to the penis to achieve and maintain an erection. It belongs to the phosphodiesterase type 5 (PDE 5) inhibitors group of drugs. This drug is primarily used for the treatment of pulmonary arterial hypertension (PAH), in which the blood vessels in the lungs are congested with a restricted blood flow. In addition to the treatment of erectile dysfunction, Viagra offers relief from the symptoms of PAH in such individuals such as Pulmonary Arterial Hypertension (PAH).

The mechanism of action of Viagra involves inhibiting phosphodiesterase 5 (PDE5) in the smooth muscle cells of the penis, leading to the relaxation of these blood vessels and increased blood flow to the penis, resulting in an erection. PDE5 inhibitors work by blocking this enzyme, which leads to the inhibition of the release of nitric oxide (NO), an NO synthase (NET) ingredient that regulates cell signaling in the body. Viagra therefore helps to manage pulmonary arterial hypertension through increasing pulmonary blood flow, smooth muscle relaxation, and blood vessel dilation.

The safety and efficacy of Viagra in patients with ED have not been established in general, and several randomized, placebo-controlled, or dose-ranging studies have been conducted. The primary endpoint of these studies was the change in Viagra user-defined end points, such as user-defined Viagra Viagra, in terms of improvement on pulmonary exercise index (PEI), blood pressure, or other clinical response measures such as global endothelial function (AEBP), sudden erections, and ejaculation rates. Secondary end points included ejaculation frequency, Viagra PEI, change in sexual satisfaction subscale (eSHS), and change in sexual satisfaction (eFTS), and sexual satisfaction (TSS) subscale (eFTS).

A total of 28 placebo-controlled trials were conducted to evaluate the effects of Viagra on clinical outcomes such as user-defined PEI, change in sexual satisfaction, change in sexual satisfaction subscale, and change in sexual satisfaction subscale. Of these trials, 13 included 28 participants in a dose-ranging randomized, double-blind, placebo-controlled, 24-week extension study. The overall results in terms of change in sexual satisfaction in the study conducted with Viagra over a 4-week period demonstrated that participants in the Viagra-treated group reported significantly greater improvements in PEI, change in sexual satisfaction, and change in sexual satisfaction subscale compared to participants in the study conducted with a placebo. These results are promising and confirm the safety and efficacy of Viagra over a 4-week period in patients with ED.

The mechanism of action of Viagra involves inhibiting phosphodiesterase type 5 (PDE5) in the smooth muscle cells of the penis, leading to the relaxation of these blood vessels and increased blood flow to the penis, resulting in an erection. PDE5 inhibitors work by blocking this enzyme, and the medication enhances smooth muscle relaxation and blood flow, leading to the inhibition of NOISA and ejaculation rates.

The efficacy of Viagra in men with ED has been demonstrated in two clinical trials: a 2-week, double-blind, placebo-controlled study conducted with Viagra (sildenafil citrate) to assess the safety and efficacy in men with ED who have difficulty achieving or maintaining an erection. The study assessed the efficacy in men with ED that was symptomatic of mild to moderate degrees of ED, where Viagra was used as needed, and men with ED that was severe (PEI >35%) where the ejaculation frequency was less than four hours. In this 2-week extension study, the overall results in terms of change in sexual satisfaction, sexual satisfaction subscale, and change in sexual satisfaction subscale compared to those in the study conducted with placebo showed a reduction in the severity of ED. These results are promising, as demonstrated in the study conducted with Viagra over a 4-week period. These results are also consistent with the safety and efficacy of Viagra over a 4-week period in patients with ED.

In the 3-week, double-blind, placebo-controlled clinical trial with Viagra (sildenafil citrate), participants were required to use a 50 mg tablet daily for 4 days, and the efficacy of Viagra in achieving an erection was evaluated using the International Index of Erectile Function (IIEF) scale.

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